The Hoxton Rome brings East London's boutique hotel charm to Rome's vibrant Salario neighborhood. With 192 rooms showcasing mid-century Italian design, from Shoebox to Biggy sizes, plus two standout restaurants—Cugino for all-day dining and Elio for Roman fare—it's perfectly positioned near Villa Borghese and world-class museums. Accessible luxury meets authentic Roman life in this stylish, welcoming retreat.

housed in a stunning 1925 Art Nouveau building with roots dating to 1905, Hotel Locarno has been Rome's boutique hotel pioneer since the 1970s. This historic hideaway combines multiple layers of glamorous history with contemporary luxury. From atmospheric rooms to legendary suites, plus a celebrated bar serving inventive cocktails to Rome's creative elite for decades, it offers unmatched depth and eccentric charm that modern hotels simply cannot replicate.

Hotel Vilòn occupies a romantic 16th-century house annexed to Palazzo Borghese in Rome's historic center. Once a 20th-century nunnery, this intimate 18-room boutique hotel offers monastic quiet amidst the bustling city. Designed by architect Giampiero Panepinto and film set designer Paolo Bonfini, each cinematic room features walk-in closets, complimentary minibars, and garden views. Adelaide Ristorante serves seasonal Italian cuisine on terraces overlooking private gardens.

JK Place Roma is housed in Rome's former school of architecture near the Spanish Steps. Michele Bönan's designs create a boutique hotel with just thirty rooms and suites, offering ultra-discreet service and posh seclusion. The stylish JK Café serves as an all-day bar and lounge. This intimate retreat prioritizes personalized luxury over comprehensive facilities, making it the perfect place to contemplate a permanent Roman holiday in the heart of the city.

Singer Palace Hotel occupies the historic Art Deco palazzo built for Singer sewing machines nearly a century ago on Via del Corso, Rome's premier shopping street. This boutique hotel blends period architecture with contemporary art and modern design furniture. With 29 unique rooms and suites featuring parquet floors and marble bathrooms, it offers surprisingly spacious accommodations. The rooftop restaurant and bar serve breakfast, lunch, and dinner with views over the Eternal City.

The meticulously restored 15th-century Palazzo Salviati Cesi Mellini, is now home to Six Senses Rome. Designer Patricia Urquiola created thoroughly modern luxury interiors that pay tribute to Rome's history while embracing contemporary Italian design. Rooms start at 28 square meters with vast top-tier suites. The lavish spa offers Roman baths, and dining includes NOTOS Rooftop terrace and BIVIUM's sustainable, half plant-based menu focused on local ingredients.

Hotel Hassler Roma sits at the top of the Spanish Steps, owned by the same Swiss family since the 1890s. This luxury institution combines warm hospitality with professional operation in unique rooms and suites. Features include the MICHELIN-starred Imàgo restaurant with panoramic city views, the 1940s-inspired Hassler Bar, Amorvero Spa, and lavish accommodations ranging from classic doubles to the ornate Villa Medici and modern Hassler penthouses.

Hidden down a quiet alleyway next to Rome's famous Forum is The Inn at the Roman Forum, known for its unique rooms with whirlpool baths, plasma TVs, and Etro bath products. This charming retreat features garden and rooftop terraces perfect for sunset cocktails. The greatest surprise lies beneath: an authentic millennia-old Roman crypt accessible via a doorway behind reception. Few boutique hotels can match this extraordinary amenity in their centuries-old building.

Portrait Roma sits above the flagship Ferragamo store in a 19th-century townhouse, representing the family's luxury hospitality venture. Michele Bonan's elegant design features ultra-luxe details like boarskin leather elevators and silk curtains. Rooms offer petite balconies overlooking the streets below. The rooftop lounge serves cocktails by the fireplace with Spanish Steps views, while the penthouse boasts its own kitchen, sauna, and private terrace.

Private and discrete, Umiltà 36 is tucked away on a side street near the Trevi Fountain, connected to Via del Corso. This luxury boutique hotel features vibrant interiors blending Art Deco glamour with classic modernism and contemporary art. Elegantly designed rooms and suites embrace refined simplicity, while inviting public spaces include Dandy Café restaurant and fresh seafood restaurant Aquamarina.